多能性幹細胞作成特許・ 多能性幹細胞バンキング特許

弊社の代表取締役Chairである菅谷博士は2005年に癌化する遺伝子を使用することなく 

多能性幹細胞を間葉系幹細胞から作成する技術を開発(2005年特許申請、認可済)

遺伝子の導入を用いないでIPSを作成する新しい技術
(2018年特許申請)を開発。


そして将来的な再生医療のために修飾成人幹細胞バンキングの特許(2006年特許申請、認可済) を

保有しており、それらの特許技術の許諾実施を行っております。

Not implicated in Yamanaka's study was nanog, which like oct3/4 and sox2 is also a key transcriptional regulator in pluripotent cells. Kiminobu Sugaya, director of the Stem Cell Laboratory at the University of Central Florida, has presented data at meetings showing that adult mesenchymal stem cells-bone marrow-derived cells that are predestined to form connective tissues like bone and cartilage-can be dedifferentiated into embryonic-like stem cells by expression of nanog.

According to Kevin Eggan, assistant professor of molecular and cellular biology at Harvard University, others have shown that nuclear reprogramming during cell fusion can likewise be made more efficient by overexpression of nanog in mouse embryonic stem cells.

2007年4月20日発行 【LIFE SCIENCE TECHNOLOGIES】 より抜粋
https://www.sciencemag.org/site/products/lst_20070420.pdf 

【特許概要】

【多能性幹細胞作成特許 概要】

Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage. 

 有効期限:2028年8月6日まで有効


【多能性幹細胞バンキング特許概要】

Disclosed herein are methods for producing a stem cell bank and providing stem cell samples for purchase or use. Also, provided herein are embodiments relating to a stem cell bank and stem cell banking system. 
詳細:https://patents.google.com/patent/US8759090B2/en

論文

Potential Therapeutic Approaches for Stroke Using Induced Pluripotent Stem Cells,
Valerio LSA and Sugaya K*,  Austin Journal of Biomedical Engineering, 2014 ;1(4): 10-16
https://austinpublishinggroup.com/biomedical-engineering/fulltext/ajbe-v1-id1016.php


Nanog Overexpression Increases Neural Marker Expression in Adipose Derived Stem Cells,
Jacob Kimmel and Kiminobu Sugaya*,
 Recent Patent on Regenerative Medicine, 2014, 4(1) 69-74 .https://www.ingentaconnect.com/content/ben/rpgm/2014/00000004/00000001/art00006


Induced Pluripotent Stem Cells: Current and Emerging Technologies,
Jacob Kimmel and Kiminobu Sugaya* (2013).  Pluripotent Stem Cells,
ISBN: 978-953-51-1192-4, InTech, DOI: 10.5772/55101.
https://www.intechopen.com/books/pluripotent-stem-cells/induced-pluripotent-stem-cells-current-and-emerging-technologies


 DNA Demethylation of Human Mesenchymal Stem Cells Has Increased Potential to Become Neuronal Cells in Human Mesenchymal and Embryonic Stem Cells
Fokhrul Hossain and Kiminobu Sugaya*,(2011)
 ISBN: 978-1-62081-909-8(Editors: Prasad S. Koka) pp.97-108
https://www.novapublishers.org/catalog/product_info.php?products_id=22629 


Stem cells for the treatment of neurodegenerative diseases,
Dantuma, E., Merchant, S. and Sugaya, K*.
 2010 Stem Cell Res Ther, 1(5) 37-45
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025439/


Nanog overexpression allows human mesenchymal stem cells to differentiate into neural cells --Nanog transdifferentiates mesenchymal stem cells
Angel Alvarez, Monowar Hossain, Elise Dantuma, Stephanie Merchant, Kiminobu Sugaya*,
Neuroscience & Medicine, 2010,1(1) 1-13
https://www.scirp.org/journal/PaperInformation.aspx?PaperID=2675


STEM CELLS: BEYOND SOMATIC CELL NUCLEAR TRANSFER
https://www.sciencemag.org/site/products/lst_20070420.pdf


Stem Cell Therapy for Alzheimer's Disease. In Advances in Alzheimer's and Parkinson's Disease
Sugaya, K.*  pp 255-264 
https://link.springer.com/chapter/10.1007/978-0-387-72076-0_25


 Survival and early differentiation of human neural stem cells transplanted in a nonhuman primate model of stroke.
Roitberg BZ, Mangubat E, Chen EY, Sugaya K, Thulborn KR, Kordower JH, Pawar A, Konecny T, Emborg ME: J Neurosurg. 2006 Jul;105(1):96-102.
https://thejns.org/view/journals/j-neurosurg/105/1/article-p96.xml


 Autologous Stem Cell Strategies for Neurological Conditions.
Sugaya, K
Interface of Basic Science and Psychogeriatrics. Thursday, 21 August 2003
https://asm.confex.com/ipa/11congress/techprogram/paper_2844.htm


Human neural stem cells improve cognitive function of aged brain.
Qu, T., C. Brannen, M. Kim and K. Sugaya:*
NeuroReport. 12: 1127-1132, May 2001
https://insights.ovid.com/article/00001756-200105080-00016

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